Skripsi-skripsi Farmasi

Pengambilan sampel dilakukan secara purposive sampling dengan kriteria: masyarakat kelurahan Gedongkiwo, kecamatan Mantrijeron, kota Yogyakarta yang akan, sedang atau telah melakukan pembelian obat generik, berumur lebih dari 15 tahun dan berpendidikan minimal SLTP, memiliki pekerjaan dan pendapatan (gaji). Jumlah sampel yang digunakan sebanyak 150 orang yang diambil secara proporsional dan random dari 18 RW. Metode analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian ini menunjukkan: (1) Rata-rata skor minat untuk membeli obat generik sebesar 3,11 dengan deviasi standar 0,45. Hal ini menunjukkan bahwa minat masyarakat Gedongkiwo untuk membeli obat generik tergolong kuat. (2) Variabel yang lebih kuat pengaruhnya terhadap minat masyarakat Gedongkiwo untuk membeli obat generik adalah norma subjektif. Hal ini ditunjukkan oleh nilai koefisien regresi baku β2=0,494, yang lebih besar dibanding nilai koefisien regresi baku variabel sikap (β1=0,446). Kata kunci: obat generik, sikap, norma subyektif, minat ABSTRACT Introduction Colorectal cancer (CRC) are the second most common of cancerrelated deaths in developed countries. In Indonesia, the incidence of colon and rectal cancer ranks as one of the ten most common cancer in country. Observation from the archived data especially in RS Dr Sardjito showed the increased in numbers in the most recent consecutive years alone, 2002 to 2004. The barium enema examination (BEE) is the mainstay of radiologic in detection of colorectal cancer. It is an accurate, cost-effective, and safe method with the overall sensitivity is greater than 90% for the detection of adenomas larger than 1 cm. There are two types of BEE namely single contrast and double contrast barium enema. The double contrast examination has greater sensitivity for the detection of lesions smaller than 1 cm. Usually, both are being used in the radiologic setting in detecting CRC which the timely diagnosis later was confirmed by histopathologic test as gold standard procedure. The objective of the study was to determine the accuracy of BEE as routinely performed in the detecting clinically important CRC in RS DR Sardjito, as well as to correlate between BEE and histopathological finding. The hypothesis was, BEE was accurate and has a correlation with histopathological finding in detecting CRC. Method Retrospective-descriptive study was carried out on 223 subjects of CRC whose undergone Colon In Loop with BEE and histopathological examination from January 2002 to December 2004. The aim in this study was to evaluate the accuracy of barium enema in detecting CRC at RS Dr Sardjito with the used of histopathological findings as a gold standard. Data were analyzed using Table 2 X 2 and Spearman rank correlation. Results The results showed a significance (p<0.05) between the BEE and histological finding in detecting CRC. However, the accuracy of BEE was not high enough due to the biases that occurred in the study design (82%). Conclusion The hypothesis was accepted. The utility of barium radiography mostly dependent upon the skill of the radiologist in reading the subtleties of the resultant film. Additionally, successful studies are dependent upon the patient’s preparation and cooperation during the procedure as well as the result interpretation and double reading from the histopathological findings. Keywords:Barium enema, detection, colorectal cancer,histopathologic.

Category: Skirpsi , TESIS